Superficial granulomatous pyoderma. Report of 2 cases treated with topical tacrolimus.

Superficial granulomatous pyoderma (SGP) or pyoderma vegetans is a rare inflammatory disease first described by Wilson-Jones and Winkelmann in 1988. Although considered a superficial, vegetative variant of pyoderma gangrenosum (PG), SGP has distinguishing features such as a chronic and slowly progressive course, lack of association with other diseases, shallower ulcers, the presence on histology of characteristic 3-layered granulomas, and better response to treatment (Table 1). We present 2 cases of SGP that were successfully treated with topical tacrolimus, with no recurrence after 5 years.